• Liam’s Passing

    by  • 21 September 2015 • 3 Comments

    21Sept2015 – Liam took his last breath at 4:36 am. His departure from this life was peaceful. Fred and I were by his side. 2 Timothy 4:7-8 “I have fought the good fight, I have finished the race, I have kept the faith. Now there is in store for me the crown of righteousness,...

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    by  • 7 August 2015 • 2 Comments

    The first chemotherapy drugs in Liam's treatment were topotecan and cyclophosphamide. He received two five-day treatments with these drugs. The first was during Aug 2014 and the second was in Sept. 2014 (separated by four weeks). The drugs are given together for a combined treatment that offers a synergistic effect. In his case,...

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    DNA Replication and Torsional Strain

    by  • 1 August 2015 • 1 Comment

    A Schematic / Block Diagram Many enzymes work together in the replication of DNA. The focus of this post will be on the topoisomerase enzymes and their function. In another upcoming post, I will introduce topoisomerase inhibitors. It is important to understand what is going on with these enzymes and how the topoisomerase enzymes work...

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    Some DNA Basics

    by  • 29 July 2015 • 1 Comment

    Deoxyribonucleic acid (DNA) There Is a Lot of It. As we have mentioned before in a different post, there are about 3 billion base pairs of DNA over 46 chromosomes (23 pairs).  This count is for each cell in your body. You have about 70 trillion cells in your body. Yes, that is 70,000,000,000,000 copies of...

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    mIBG – We are back on!

    by  • 25 July 2015 • 2 Comments

    For those avid followers of all of the science that I have introduced during all of this, you will recognize that this post is a rehash, but an exciting rehash. Early on, Liam was initially slated to participate in a mIBG (MetaIodoBenzylGuanidine) trial.  The trial wasn’t supposed to happen until after the induction period of...

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    Gene Blues and MYCN Amplification

    by  • 28 October 2014 • 1 Comment

    Neuroblastoma Genetic Testing There is a lot of stuff that is not known about Neuroblastoma, but there are a few key markers on the genetic sequence that have had some statistics gathered and can provide an inkling of whether or not the particular breed (or genetic makeup) of the Neuroblastoma is going to be more (or...

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    Cancer is Wood

    by  • 11 October 2014 • 6 Comments

    ...This was a task that neither Fred nor I had ever done before-alone or together, in good weather or bad. But we tackled it together and managed to enjoy a rather miserable time together. We took turns, we encouraged one another, we laughed, we borrowed a joke from the sitcom "Boy Meets World" that...

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